There is a large body of neurochemical and anthropological evidence which suggests that the pineal gland may produce a neuro-modulator that enhances a psi-conducive state of consciousness. An abstract of this research was presented at the Parapsychological Association Convention in 1985 (Roney-Dougal, 1986). For full details of this research please see Roney-Dougal (1988, 1989, 1990, 1991, 1993). In brief, the pineal gland has been found to synthesize various beta-carbolines and peptides, and to contain enzymes that produce psycho-active compounds such as 5-methoxy dimethyltryptamine (5MeODMT). “The two precursors that are most likely to be involved in the synthesis of such compounds are serotonin (5-hydroxytryptamine, 5HT) and tryptamine” (Strassman, 1990). These have wide-ranging effects throughout our brain and body, affecting the gonads, adrenals, pancreas, thyroid, and other emotional and endocrine activities.
Of most interest here are the neuromodulators called beta-carbolines which are MAO inhibitors that prevent the breakdown of serotonin. This results in an accumulation of physiologically active amines within the neuronal synapses which may lead to hallucinations, depression or mania depending on the amines being affected (Strassman, 1990). Beta-carbolines are also found in the retina of the eyes, in the adrenal glands and in the gut. The pineal contains the greatest concentration of serotonin in the brain, this being accentuated in those who suffer from psychoses. The pineal also contains enzymes that inhibit synthesis of these compounds, thus suggesting a regulating mechanism within this gland. There is a suggestion that it is the action of the pineal beta-carbolines, in particular 6-Methoxytetrahydrobetacarboline (6MeOTHBC, now being called pinoline), on serotonin that triggers dreaming (Callaway, 1988). Spontaneous case collection studies (e.g. Rhine, 1969) have found that many spontaneous psi experiences occur during the sleeping and dreaming state of consciousness, which suggests that dreaming is a state of consciousness whereby we are likely to have psi experiences. This has been confirmed experimentally (Ullman, Krippner & Vaughan, 1973). Pinoline is suggested to be the neurochemical that triggers this particular state of consciousness.
Anthropological data also suggest that these beta-carbolines are psi-conducive because their chemical structure is very similar to a naturally occurring group of chemicals called harmala alkaloids which occur in an Amazonian vine, Banisteriopsis caapi, used by Amazonian tribes for psychic purposes (Roney-Dougal, 1986 & 1989) (See Figure 2). The Amazon has a huge variety of psychotropic plants, yet all the tribes throughout that vast area use this same vine mixed with Psychotria viridis (Nai kawa) which contains dimethyltryptamine (DMT) (Ott, 1993 & 1994), for healing, out-of-body experiences, clairvoyance and precognition. It is traditionally used only when psi experiences are desired, though nowadays it is also used for general initiatory purposes. Thus the tribal people make a mixture of harmala alkaloids and DMT which mimics the tryptamine-pinoline mixture ascribed to the night time output of the pineal gland. My speculation is that when the pineal gland is stimulated to produce pinoline we are more likely to enter an altered state of consciousness which is psi-conducive.
In the 1960s a Chilean psychotherapist, Claudio Naranjo (1973, 1978) used a variety of hallucinogens including harmaline (one of the harmala alkaloids) in the psychotherapeutic setting, and came to the conclusion that: “Harmaline may be said to be more hallucinogenic than mescaline. . .both in terms of the number of images reported and their realistic quality. In fact some subjects felt that certain scenes which they saw had really happened and that they had been as disembodied witnesses of them in a different time and space. This matches the experience of South American shamans.” (Naranjo, 1967). Ott (1993) considers that the harmala alkaloids are not actually hallucinogenic in their own right, but that they permit the DMT in the ayahuasca mixture to be absorbed into the blood stream so that these create the entheogenic effects. This is still a matter of debate. There is extensive evidence from many anthropologists which suggests that the Banisteriopsis vine together with Psychotria Viridis is a psi-conducive drug, particularly with regard to remote viewing, clairvoyance and precognition but so far there has been no experimental test of these claims (Kensinger, 1973). Ayahuasca has recently been investigated by Don et al (1996) who suggested that its action is consistent with their other research into brain function and psi experience.
Thus, the anthropological evidence suggests that harmala alkaloids mixed with DMT stimulate a psi-conducive state of consciousness; the neurochemical evidence suggests that the harmala alkaloids are an analogue of pinoline which is produced in the pineal gland, noting that in the comparison between the action of the harmala alkaloids and pinoline it must be remembered that a one-position change in methoxy grouping can be profound in its action. The yogic and occult teachings and common folk lore all say that the pineal gland is the psychic centre and I suggest that the pinoline made by the pineal gland at night time, through its action on seratonin, stimulates a dream type state of consciousness which is psi-conducive.
1 comment:
Great post. Research Dan Winter and I think you might be pleasantly surprised.
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